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  • Carisoprodol is a centrally-acting skeletal muscle relaxant whose active metabolite is meprobamate. Although several case reports have shown that carisoprodol has abuse potential ...

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  • carisoprodol /car·iso·pro·dol/ (kar?i-so-pro´dol) an analgesic and skeletal muscle relaxant used to relieve symptoms of acute painful skeletomuscular disorders.

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Carisoprodol
Systematic (IUPAC) name
aminomethanoate
Identifiers
CAS number78-44-4
ATC codeM03BA02
PubChem2576
DrugBankAPRD00417
ChemSpider2478
Chemical data
FormulaC12H24N2O4 
Mol. mass260.33 g/mol
Pharmacokinetic data
Bioavailability ?
Protein binding60%
MetabolismHepatic (CYP2C19-mediated)
Half life8 hours
ExcretionRenal
Therapeutic considerations
Pregnancy cat.

?

Legal status

â„ž-only(US) Schedule III in these U.S. states: Alabama, Arkansas, Arizona, Florida, Georgia, Hawaii, Indiana, Kentucky, Massachusetts, Minnesota, Nevada, New Mexico, Oklahoma, Oregon and West Virginia.

RoutesOral

Carisoprodol is a centrally-acting skeletal muscle relaxant whose active metabolite is meprobamate. Although several case reports have shown that carisoprodol has abuse potential both by itself and as a potentiator of hydrocodone, dihydrocodeine, codeine and similar drugs, it continues to be widely prescribed in North America. In Europe, doctors favor cyclobenzaprine due to its lower abuse factor. In the United Kingdom, benzodiazepines are preferred instead. Carisoprodol is a colorless, crystalline powder, having a mild, characteristic odor and a bitter taste. It is slightly soluble in water and freely soluble in alcohol, chloroform and acetone. Its solubility is practically independent of pH.

Carisoprodol is marketed in the United States under the brand name Soma, and in the United Kingdom and other countries under the brand names Sanoma and Carisoma. Carisoprodol is especially useful against various types of pain (whether or not related to muscle spasm) because of its analgesic-sparing (potentiating) effect on opioid analgesics. Carisoprodol is available by itself or mixed with aspirin and in one preparation (Soma Compound With Codeine) along with codeine and caffeine as well.

As of November 2007 Carisoprodol (Somadril, Somadril comp.) has been taken off the market in Sweden due to problems with dependence, abuse and side effects. The agency overseeing pharmaceuticals has considered other drugs used with the same indications as carisoprodol to have the same or better effects without the risks of the drug. In the EU, the European Medicines Agency has issued a release recommending that member states suspend marketing authorization for this product.

As of July 2002 Carisoprodol is considered to be a schedule CIV by the State of Florida. A state bill was passed due to a recent understanding that the drug is becoming more widely abused. Possession of the drug without a valid prescription in the state of Florida is now a third degree felony. The rest of the United State falls under the DEA scheduling for the drug, which considers carisoprodol a non-schedule chemical.

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About Carisoprodol

Carisoprodol 325mg Aspirin 200mg
CarisoprodolSystematic (IUPAC) nameaminomethanoateIdentifiersCAS number78-44-4ATC codeM03BA02PubChem2576DrugBankAPRD00417ChemSpider2478Chemical dataFormulaC12H24N2O4 Mol. mass260.33 g/molPharmacokinetic dataBioavailability ?Protein binding... Read more
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  • Carisoprodol is a certified muscle relaxant and pain reliever in one. It works by binding itself to the opioid receptors (pain receptors) in the brain to intercept pain sensations before it get to the corresponding receptors in the brain. When used in addition to rest, exercise, and a healthy lifestyle, carisoprodol's efficacy can be maximized.


  • Carisoprodol is marketed in the United States


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