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  • Vicodin ® Vicodin ® is a combination of Hydrocodone and Acetaminophen. Hydrocodone belongs to a group of drugs called narcotic pain relievers.

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  • What is Vicodin (Acetaminophen Hydrocodone)? Hydrocodone is in a group of drugs called narcotic pain relievers. Acetaminophen is a less potent pain reliever that increases the ...

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This article or section is missing citations or needs footnotes.
Using inline citations helps guard against copyright violations and factual inaccuracies. (November 2008)
Hydrocodone
Systematic (IUPAC) name
4,5a-Epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5)
Identifiers
CAS number125-29-1
ATC codeR05DA03
PubChem5284569
DrugBankAPRD00591
ChemSpider4447623
Chemical data
FormulaC18H21NO3 
Mol. mass299.368
SMILESeMolecules & PubChem
Synonymsdihydrocodeinone
Pharmacokinetic data
BioavailabilityHigh
MetabolismHepatic
Half life3.8 hours
Excretion ?
Therapeutic considerations
Pregnancy cat.

Category C (USA)

Legal status

Class A(UK) Schedule II in bulk quantities or as stand-alone product; Schedule III when in combination product (USA)

RoutesOral, intravenous, intramuscular, subcutaneous, sublingual, intranasal

Hydrocodone or dihydrocodeinone is a semi-synthetic opioid derived from two of the naturally occurring opiates, codeine and thebaine. Hydrocodone is an orally active narcotic analgesic and antitussive. It is commonly available in tablet, capsule, and syrup form and is often compounded with other analgesics like paracetomol or ibuprofen. It is marketed, in its varying forms, under a number of trademarks, including Vicodin, Symtan, Anexsia, Dicodid, Hycodan (or generically Hydromet), Hycomine, Hycet, Lorcet, Lortab, Norco, Novahistex, Hydrovo, Duodin, Kolikodol, Orthoxycol, Mercodinone, Synkonin, Norgan, and Hydrokon. Hydrocodone was first synthesized in Germany in 1920 and was approved by the FDA on 23 March 1943 for sale in the United States under the brand name Hycodan.

The particular niches in which hydrocodone is most commonly used is as an intermediate-strength centrally-acting analgesic and strong cough suppressant, especially in those for whom histamine release and attendant itching from codeine is a problem. For the latter indication, at the 5-10 mg dose range hydrocodone is more powerful than most cough suppressants, being roughly equal to its derivative thebacon and with the top of the list being hydromorphone (Dilaudid Cough Syrup) and methadone (Methadone linctus, about 33 per cent the concentration of the liquid used for opioid physical dependence maintainence or detoxification).

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Post Surgery (as promised) 553
This article or section is missing citations or needs footnotes.Using inline citations helps guard against copyright violations and factual inaccuracies. (November 2008)HydrocodoneSystematic (IUPAC) name4,5a-Epoxy-3-methoxy-17-methylmorphinan-6-one ... Read more
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